Plasma F^sub 2^-Isoprostanes and Coronary Artery Calcification: The CARDIA Study

From: Clinical Chemistry | Date: January 1, 2005| Author: Et al; Jacobs, David R Jr; Steffes, Michael; Yu, Xinhua; Gross, Myron | Copyright information

Background: Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease.

Method and Results: We assayed F^sub 2^-isoprostanes, oxidation products of arachidonic acid, by gas chromatography-mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stage...

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