^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats From: The Journal of Nuclear Medicine | Date: December 1, 2004| Author: Hatada, Kengo; Riou, Laurent M; Ruiz, Mirta; Yamamichi, Yoshihiro; Et al | Copyright Society of Nuclear Medicine Dec 2004. Provided by ProQuest LLC.Copyright information

^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five anesthetized Sprague-Dawley rats were injected intravenously with 22.2-29.6 MBq ^sup 99m^Tc-N-DBO...