^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats

The Journal of Nuclear Medicine | December 1, 2004| | Copyright

^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five anesthetized Sprague-Dawley rats were injected intravenously with 22.2-29.6 MBq ^sup 99m^Tc-N-DBODC5 (n = 25), ^sup 99m^Tc-sestamibi (n = 25), or ^sup 99m^Tc-tetrofosmin (n = 25). Rats were ...

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