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Glomerular injury induced in mice by intraperitoneal injection of Shiga-like toxins
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Background & objectives : Shiga-like toxins I and II (Stx1 and Stx2) play an important role in the pathogenesis of renal disease by causing renal microvascular injury. A murine model was used to study glomerular lesions produced by Stx1 and Stx2.
Methods : Swiss albino mice of the Rockefeller strain were inoculated intraperitoneally with LD 50 doses of endotoxin-free Stx1 or Stx2 and observed for signs of disease. Samples of renal cortical tissue from mice were examined with the electron microscope.
Results : The mice developed systemic and neurological symptoms including hind limb ...
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