Bioluminescence Imaging of the Response of Rat Gliosarcoma to ALA-PpIX-mediated Photodynamic Therapy¶ From: Photochemistry and Photobiology | Date: September 1, 2004| Author: Bisland, Stuart K; Lilge, Lothar; Wilson, Brian C; Moriyama, Eduardo H | Copyright American Society of Photobiology Sep/Oct 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT

Photodynamic therapy (PDT) is a promising modality for the treatment of solid tumors that combines a photosensitizing agent and light to produce cytotoxic reactive oxygen species that lead to tumor cell death. The recent introduction of bioluminescence imaging (BLI), involving the use of the luciferase gene (luc) transferred into target tumor cells, followed by systemic administration of luciferin and detection of the emitted visible chemiluminescence photons, offers the poten...

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