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Molecular and Metabolic Imaging of Atherosclerosis*
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Atherosclerosis is a systemic disease that affects most major arteries of the body and is the most common cause of premature death in the western world. It develops slowly and often asymptomatically, so that for many patients its first manifestation is sudden cardiac death, stroke, or myocardial infarction. The current gold standard for imaging atherosclerosis is x-ray angiography. However, recent advances in understanding of the pathobiology of atherosclerosis have highlighted the inadequaci...
Related newspaper, magazine, and journal articles from HighBeam Research
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Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
The Journal of Nuclear Medicine
; ^sup 111^In-Labeled antibodies and peptides have been routinely used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent studies have shown that there are significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium
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Molecular and Metabolic Imaging of Atherosclerosis*
The Journal of Nuclear Medicine
; Atherosclerosis is a systemic disease that affects most major arteries of the body and is the most common cause of premature death in the western world. It develops slowly and often asymptomatically, so that for many patients its first manifestation is sudden cardiac death, stroke, or myocardial
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Association of Vascular ^sup 18^F-FDG Uptake with Vascular Calcification
The Journal of Nuclear Medicine
; Both calcification and FDG uptake have been advocated as indicators of atheroma. Atheromas calcify as cells in the lesion undergo apoptosis and necrosis during evolution of the lesion and at the end stage of the lesion. FDG concentrates in lesions due to the relatively dense cellularity in regions
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Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice
Genetics
; ABSTRACT We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J CAST/Ei) F^sub 2^ cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate gene in this region. Subsequent studies with the 5LO knockout model showed effects on
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First Evaluation of a ^sup 99m^Tc-Tricarbonyl Complex, ^sup 99m^Tc(CO)^sub 3^(LAN), as a New Renal Radiopharmaceutical in Humans
The Journal of Nuclear Medicine
; ^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3), ^sup 99m^Tc-DD- and LL-ethylene-dicysteine (^sup 99m^Tc-EC), and ^sup 99m^Tc-mercaptoacetamide-ethylene-cysteine (^sup 99m^Tc-MAEC) contain N^sub 3^S or N^sub 2^S^sub 2^ ligands designed to accommodate the 4 ligating sites of the (^sup
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STUDY OF A NOVEL [Cu^sup II^(TPP)]/NAFION FILM ELECTRODE FOR THE DETECTION OF NITRIC OXIDE RADICAL (NO)
Collection of Czechoslovak Chemical Communications
; ... Anal. Chem. 1994, 66, 3882. 16. Guadalupe A. R., Liu K. E., Abruna H. D.: Electrochim. Acta 1991, 36, 881. 17. Park J.-K., Tran P. H., Chao J. K. T., Qhodadra R., Rangarajan R., Thakor N. V.: Biosens. Bioelectron. 1998, 13, 1187. 18. Joseph J., Kalyanaraman ...
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Pharmacological basis of different targets for the treatment of atherosclerosis
Journal of Cellular and Molecular Medicine
; Abstract The development of atherosclerotic plaque is a highly regulated and complex process which occurs as a result of structural and functional alterations in endothelial cells, smooth muscle cells (SMCs), monocytes/macrophages, T-lymphocytes and platelets. The plaque formation in the coronary
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^sup 18^F-FDG Accumulation in Atherosclerotic Plaques: Immunohistochemical and PET Imaging Study
The Journal of Nuclear Medicine
; The rupture of atherosclerotic plaques and the subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Thus, the detection of vulnerable plaques in atherosclerotic lesions is a desirable goal, and attempts to image these plaques with ^sup 18^F-FDG
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Targeting of endothelin receptors for molecular imaging of atherosclerosis in rabbits
The Journal of Nuclear Medicine
; We wanted to determine whether a previously described in vivo accumulation of a ^sup 99m^Tc-labeled endothelin derivative in atherosclerotic lesions is mediated by binding to endothelin receptors. Furthermore, the expression of endothelin receptors in atherosclerotic lesions of 2 different rabbit
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Noninvasive Imaging of Atherosclerosis: The Biology Behind the Pictures
The Journal of Nuclear Medicine
; It is now realized that atherosclerotic plaques do not always impinge on lumen diameter and that clinical events due to plaque rupture, such as myocardial infarction and stroke, occur more as a consequence of plaque composition than of size. The inflammatory cell content of plaque is the most
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