Pressure Denaturation of Staphylococcal Nuclease Studied by Neutron Small-Angle Scattering and Molecular Simulation

Biophysical Journal | November 1, 2004| | Copyright

ABSTRACT

We studied the pressure-induced folding/unfolding transition of staphylococcal nuclease (SN) over a pressure range of ~1-3 kilobars at 25°C by small-angle neutron scattering and molecular dynamics simulations. We find that applying pressure leads to a twofold increase in the radius of gyration derived from the small-angle neutron scattering spectra, and P(r), the pair distance distribution function, broadens and shows a transition from a unimodal to a bimodal distribution as the protein unfolds. The results indicate that the globular structure of SN is retained across the ...

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