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An All-Atom Force Field for Tertiary Structure Prediction of Helical Proteins
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ABSTRACT
We have developed an all-atom free-energy force field (PFF01) for protein tertiary structure prediction. PFF01 is based on physical interactions and was parameterized using experimental structures of a family of proteins believed to span a wide variety of possible folds. It contains empirical, although sequence-independent terms for hydrogen bonding. Its solvent-accessible surface area solvent model was first fit to transfer energies of small peptides. The parameters of the so...
Related newspaper, magazine, and journal articles from HighBeam Research
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An All-Atom Force Field for Tertiary Structure Prediction of Helical Proteins
Biophysical Journal
; ABSTRACT We have developed an all-atom free-energy force field (PFF01) for protein tertiary structure prediction. PFF01 is based on physical interactions and was parameterized using experimental structures of a family of proteins believed to span a wide variety of possible folds. It contains
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Touchstone II: A new approach to ab initio protein structure prediction
Biophysical Journal
; ABSTRACT We have developed a new combined approach for ab initio protein structure prediction. The protein conformation is described as a lattice chain connecting C^sub [alpha]^ atoms, with attached C^sub [beta]^ atoms and side-chain centers of mass. The model force field includes various
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An Evolutionary Strategy for All-Atom Folding of the 60-Amino-Acid Bacterial Ribosomal Protein L20
Biophysical Journal
; ABSTRACT We have investigated an evolutionary algorithm for de novo all-atom folding of the bacterial ribosomal protein L20. We report results of two simulations that converge to near-native conformations of this 60-amino-acid, four-helix protein. We observe a steady increase of "native content" in
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Security.(Backpage Briefing)(Tiny Force Field Wireless)(Brief Article)
Telecom Asia
; SECURITY: Worried about drive-by hackers tapping into your corporate wireless LAN or home network via signals leaking out into the street? You might try a new coat of paint. Not just any old paint, of course, but paint laced with aluminum and copper. That's the pitch from Tiny Force Field Wireless,
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Importance of the CMAP Correction to the CHARMM22 Protein Force Field: Dynamics of Hen Lysozyme
Biophysical Journal
; ABSTRACT The recently developed CMAP correction to the CHARMM22 force field (C22) is evaluated from 25 ns molecular dynamics simulations on hen lysozyme. Substantial deviations from experimental backbone root mean-square fluctuations and N-H NMR order parameters obtained in the C22 trajectories
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 "AAP Sports News (Australia)")
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Crik: The force field in Adam Gilchrist's bat
AAP Sports News (Australia)
; AAP Sports News (Australia) 01-04-2005 Crik: The force field in Adam Gilchrist's bat By John Coomber, Senior Sports Writer SYDNEY, Jan 4 AAP ...
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A physical approach to protein structure prediction
Biophysical Journal
; ABSTRACT We describe our global optimization method called Stochastic Perturbation with Soft Constraints (SPSC), which uses information from known proteins to predict secondary structure, but not in the tertiary structure predictions or in generating the terms of the physics-based energy function.
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ASTRO-FOLD: A combinatorial and global optimization framework for ab initio prediction of three-dimensional structures of proteins from the amino acid sequence
Biophysical Journal
; ... prediction accuracy is the evaluation of contact maps which indicate the interatomic distances ... helices. Fig. 12 depicts comparative contact maps for four CASP5 targets: T0130, T0138, T0150 ... parallel to the diagonal. However, the contact maps also allow for assessment of topological ...
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Force Field Analysis and Strategic Management: A Dynamic Approach
Engineering Management Journal
; Abstract: This article proposes a dynamic approach to business strategy. It is assumed that the strategic position of any firm will always tend to deteriorate under the combined influences of strategic regression and market competition. Any firm adopting a status quo strategy will be subjected to a
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 "The Mirror (London, England)")
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I JUST PLANTED A FEW BULBS..; Force field of power lines lights up tubes.(News)
The Mirror (London, England)
; Byline: RICHARD SMITH A FIELD of 1,300 fluorescent tubes light up the night sky - powered solely by the force field from overhead power lines. Richard Box created the 60-metre display to show the hazards of living in the shadow of high-voltage pylons. He said: There's a crackling sound as well as
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