Predicting the Three-Dimensional Structure of the Human Facilitative Glucose Transporter Glut1 by a Novel Evolutionary Homology Strategy: Insights on the Molecular Mechanism of Substrate Migration, and Binding Sites for Glucose and Inhibitory Molecules From: Biophysical Journal | Date: November 1, 2004| Author: Fischbarg, Jorge; Iserovich, Pavel; Vera, Juan Carlos; Zuniga, Felipe; Salas-Burgos, Alexis | Copyright Biophysical Society Nov 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT

The glucose transporters (GLUT/SLC2A) are members of the major facilitator superfamily. Here, we generated a three-dimensional model for Glut1 using a two-step strategy: 1), GlpT structure as an initial homology template and 2), evolutionary homology using glucose-6-phosphate translocase as a template. The resulting structure (PDB No. 1SUK) exhibits a water-filled passageway communicating the extracellular and intracellular domains, with a funnel-like exofacial vestibule (infu...

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