Inhibition of Graft Coronary Arteriosclerosis After Heart Transplantation

From: The American Surgeon | Date: October 1, 2004| Author: Czer, Lawrence S C; Et al; Luthringer, Daniel; Wang, Hai-Mei; Soukiasian, Harmik J | Copyright information

Graft coronary arteriosclerosis (GCA) is the leading cause of long-term mortality after heart transplantation (HTx). The goal of this study was to demonstrate that inhibition of immunemediated injury by cyclosporine (CsA) protects the allograft from GCA. ACI-to-Lewis rat allografts were disparate in major and nonmajor histocompatibility loci. Isografts (Lewis-Lewis) were controls. Treatment groups received either olive oil or CsA at 2.5, 5, 10, or 20 mg/kg/day for 3 months. Histology (elastin...

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