Particulate Matter Air Pollution Stimulates Monocyte Release from the Bone Marrow

From: American Journal of Respiratory and Critical Care Medicine | Date: October 15, 2004| Author: Et al; Hogg, James C; Ishii, Hiroshi; Shih, Chih-Horng; Goto, Yukinobu | Copyright information

Particulate air pollution (PM^sub 10^) stimulates alveolar macrophages (AMs) to release immature granulocytes from the bone marrow (BM) into the circulation. This study was designed to determine the effect of PM^sub 10^ (ambient EHC-93 or inert carbon [CC]) instillation exposure on the monocyte release from the BM and the role of AM in this response. Monocyte precursors were labeled in the BM of rabbits in vivo by an intravenous injection of 5'-bromo-2'-deoxyuridine, and the effects of PM^sub...

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