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Nucleotide-Mediated Mucin Secretion from Differentiated Human Bronchial Epithelial Cells
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Most current cell-based models for examining the regulation of mucin secretion demonstrate low signal-to-noise ratios, making experimental manipulation and data interpretation difficult. Using adenosine triphosphate (ATP) as a mucin secretagogue, we have developed a model of agonist-induced mucin secretion in differentiated human bronchial epithelial cells. Mucin secretory signals were estimated using enzyme-linked lectin assay, and typical signals of 300-400% of baseline were observed in res...
Related newspaper, magazine, and journal articles from HighBeam Research
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Nucleotide-Mediated Mucin Secretion from Differentiated Human Bronchial Epithelial Cells
American Journal of Respiratory Cell and Molecular Biology
; Most current cell-based models for examining the regulation of mucin secretion demonstrate low signal-to-noise ratios, making experimental manipulation and data interpretation difficult. Using adenosine triphosphate (ATP) as a mucin secretagogue, we have developed a model of agonist-induced mucin
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Endothelin-1 Inhibits Mucin Secretion from Ovine Airway Epithelial Goblet Cells
American Journal of Respiratory Cell and Molecular Biology
; Mucus hypersecretion is a feature of several respiratory diseases and frequently leads to obstruction of small airways where the principal source of mucous glycoproteins (mucins), the major macromolecular constituents of mucus, are goblet cells. Hence, inhibition of mucin secretion from these cells
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A^sub 3^ Adenosine Receptor Signaling Contributes to Airway Mucin Secretion after Allergen Challenge
American Journal of Respiratory Cell and Molecular Biology
; Mucin hypersecretion is a prominent feature of obstructive airway diseases such as asthma. Clara cells conditionally produce mucin in response to inflammatory signals in a process termed mucous metaplasia. This can be followed by mucin secretion stimulated by various signaling molecules. The
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Tumor necrosis factor-(alpha) stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro
American Journal of Respiratory Cell and Molecular Biology
; Tumor necrosis factor (TNF)-ez, a pluripotent cytokine implicated in the pathogenesis of airway inflammation, has been shown to provoke hypersecretion of mucin by airway epithelial cells in vitro. In this study, we investigated potential signaling pathways mediating TNF-a-induced mucin secretion
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Small Intestinal Mucins Are Secreted in Proportion to the Settling Volume in Water of Dietary Indigestible Components in Rats
The Journal of Nutrition
; ABSTRACT The aim of this study was to clarify the effect of dietary indigestible components on small intestinal mucin secretion. We prepared polystyrene foam (PSF) with different expansion ratios (PSF-30, -60 and -90) in which powders had different settling volumes in water (SV). Rats were fed a
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POLYHEDRAL MONOCARBABORANE CHEMISTRY. FUNCTIONALITY AND ISOMERISM: REACTIONS OF THE [6-Ph-nido-6-CB^sub 9^H^sub 11^]^sup -^ ANION WITH AMINOPYRIDINES NC^sub 5^H^sub 4^NH^sub 2^ TO YIELD NEUTRAL arachno AND closo TEN-VERTEX MONOCARBABORANE DERIVATIVES
Collection of Czechoslovak Chemical Communications
; Reaction of NC^sub 5^H^sub 4^-2-NH^sub 2^ with the [6-Ph-nido-6-CB^sub 9^H^sub 11sup -^ anion (1) in the presence of hydrated FeCl^sub 3^ gives [6-Ph-9-(NC^sub 5^H^sub 4^-2-NH^sub 2arachno-6-CB^sub 9^H^sub 12^] (4) and thence [1-Ph-2-(NC^sub 5^H^sub 4^-2-NH^sub 2closo-1-CB^sub 9^H^sub 8^] (5), in
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MARCKS Regulation of Mucin Secretion by Airway Epithelium in Vitro: Interaction with Chaperones
American Journal of Respiratory Cell and Molecular Biology
; We have reported previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. The results of those studies supported a mechanism whereby MARCKS, upon phosphorylation by protein kinase
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Increased Luminal Mucin Does Not Disturb Glucose or Ovalbumin Absorption in Rats Fed Insoluble Dietary Fiber
The Journal of Nutrition
; Abstract We tested whether increased mucin secretion due to ingestion of insoluble dietary fiber (IDF) affects small intestinal nutrient absorption in rats. Polystyrene foam (PSF) with a true expansion ratio of 54.9 was used as a model for IDF with high bulk-forming properties. In Expt. 1, rats
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Modeling of the Solubilities of NiO/NiAl^sub 2^O^sub 4^ and FeO/FeAl^sub 2^O^sub 4^ in Cryolite Melts at 1300 K
Metallurgical and Materials Transactions
; Experiments to measure the solubilities of NiOTNiAl^sub 2^O^sub 4^ and FeO/FeAl^sub 2^O^sub 4^ were performed, and the results confirmed existing literature values. The solubilities of NiAl^sub 2^O^sub 4^ and FeAl^sub 2^O^sub 4^ in Al^sub 2^O^sub 3^-saturated cryolite melts at 1300 K were modeled
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LIGAND MIGRATION IN THE REACTION OF TITANIUM COMPLEXES WITH AlMe^sub 3^
Collection of Czechoslovak Chemical Communications
; Five different titanium compounds cis-[Ti951;^sup 2^-hbo)^sub 2^(OEt)^sub 20.5toluene (1), cis-[TiCl^sub 2951;^sup 2^-thp)^sub 2^] (2), [TiCl^sub 2^(edbp)^sub 2^] (3), [Ti^sub 2956;-OMe)^sub 2^(edbp)^sub 2^(Me)^sub 2^] (6), [Ti^sub 2956;-OMe)^sub 2^(edbp)^sub 2^(OMe)^sub 2^] (7) (Hhbo =
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