CYP7A1 A-278C Polymorphism Affects the Response of Plasma Lipids after Dietary Cholesterol or Cafestol Interventions in Humans1,2 From: The Journal of Nutrition | Date: September 1, 2004| Author: Hofman, Maaike K; Weggemans, Rianne M; Zock, Peter L; Schouten, Evert G; Et al | Copyright American Institute of Nutrition Sep 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT

The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important in these interindividual differences. The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7[alpha]-hydroxylase(CYP7A1). We investigated the effect of the A278-C promoter polymorphism in the CYP7A1 gene on responses of plasma lipids to an increased intake in dietary cholesterol (742 ±...