Enhancement of submicroscopic damage of the nasal epithelium by topical allergen challenge in patients with perennial nasal allergy

The Annals of Otology, Rhinology & Laryngology | March 1, 2001| | Copyright

The purposes of this study were to clarify whether damage of the nasal epithelium exists in patients with nasal allergy, and how the morphology of the epithelium changes after topical allergen challenge. Electron microscopy revealed 2 characteristic features in the nasal epithelium of patients with perennial nasal allergy - an increase in the number of epithelial cells with cytoplasmic vacuoles, and markedly widened intercellular spaces - although these changes were unclear under light microscopy. The density of vacuolated cells significantly increased 24 hours after allergen challenge. ...

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