Probing Protein Mechanics: Residue-Level Properties and Their Use in Defining Domains

From: Biophysical Journal | Date: September 1, 2004| Author: Navizet, Isabelle; Cailliez, Fabien; Lavery, Richard | Copyright information

ABSTRACT

It is becoming clear that, in addition to structural properties, the mechanical properties of proteins can play an important role in their biological activity. It nevertheless remains difficult to probe these properties experimentally. Whereas single-molecule experiments give access to overall mechanical behavior, notably the impact of end-to-end stretching, it is currently impossible to directly obtain data on more local properties. We propose a theoretical method for probing...

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