Lessons of Slicing Membranes: Interplay of Packing, Free Area, and Lateral Diffusion in Phospholipid/Cholesterol Bilayers

From: Biophysical Journal | Date: August 1, 2004| Author: Falck, Emma; Patra, Michael; Karttunen, Mikko; Hyvà ¶ nen, Marja T; Vattulainen, Ilpo | Copyright information

ABSTRACT

We employ 100-ns molecular dynamics simulations to study the influence of cholesterol on structural and dynamic properties of dipalmitoylphosphatidylcholine bilayers in the fluid phase. The effects of the cholesterol content on the bilayer structure are considered by varying the cholesterol concentration between 0 and 50%. We concentrate on the free area in the membrane and investigate quantities that are likely to be affected by changes in the free area and free volume proper...

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