HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system

From: British Journal of Biomedical Science | Date: January 1, 2003| Author: Shankarkumar, U | Copyright information

ABSTRACT

HLA-B27 is a serological specificity which encompasses an increasing number of subtypes that show varied racial/ethnic prevalence in the world. Here, data from 5129 Indians (4500 population and caste; 629 tribal) is compiled from the literature. In addition, HLA-B27 subtyping of 58 positive individuals from Maharastra is presented. Analysis revealed an increased B27 antigen frequency among the north Indian groups (>5%) compared to the south Indian groups (<5%). HLA-B27 s...

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