Folding [lambda]-Repressor at Its Speed Limit

From: Biophysical Journal | Date: July 1, 2004| Author: Gruebele, Martin; Yang, Wei Yuan | Copyright information

ABSTRACT

We show that the five-helix bundle [lambda]^sub 6-85^ can be engineered and solvent-tuned to make the transition from activated two-state folding to downhill folding. The transition manifests itself as the appearance of additional dynamics faster than the activated kinetics, followed by the disappearance of the activated kinetics when the bias toward the native state is increased. Our fastest value of 1 [mu]s for the "speed" limit of [lambda]^sub 6-85^ is measured at low conce...

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