Historical perspective: Fat replacement of the glycogen in the liver as a cause of death ...

From: Archives of Pathology & Laboratory Medicine | Date: January 1, 2001| Author: | Copyright information

FAT REPLACEMENT OF THE GLYCOGEN IN THE LIVER AS A CAUSE OF DEATH*

During efforts to produce a cirrhosis of the liver in animals with alcohol, as well as during experiments designed simply to ascertain the effects of alcohol on its structure, an accumulation of the fat in the liver cells has been found so commonly as the main alteration that a relation between alcohol and fatty changes in the liver has long been recognized.

Rosenfeld 1 furnished rather conclusive evidence of this relation by withholding glycogen-forming foods from the diet of animals fed with alcohol and observing fatty ...

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