Latent TGF-[beta] Binding Proteins: Extracellular Matrix Association and Roles in TGF-[beta] Activation

From: Critical Reviews in Clinical Laboratory Sciences | Date: January 1, 2004| Author: | Copyright information

ABSTRACT: Transforming growth factor betas (TGF-[beta]s) are multifunctional and pleiotropic growth factors. Their major effects include inhibition of cell proliferation and enhancement of extracellular matrix production. TGF-[beta]s are secreted from cells as latent complexes, consisting of matu re dimeric growth factor, the latency-associated propeptide (LAP), and a distinct gene product, latent TGF-[beta] binding protein LTBP. The secreted complex is targeted to specific locations in the extracellular matrix by the appropriate LTBP. The latent complex needs subsequently to be activated. ...

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