A Technique for Standardized Central Analysis of 6-^sup 18^F-Fluoro-L-DOPA PET Data from a Multicenter Study

The Journal of Nuclear Medicine | July 1, 2004| | Copyright

We have recently completed a large 6-^sup 18^F-fluoro-L-DOPA (^sup 18^F-DOPA) PET study comparing rates of loss of dopamine terminal function in Parkinson's disease (PD) patients taking either the dopamine agonist ropinirole or L-DOPA. This trial involved a "distributed acquisition/centralized analysis" method, in which ^sup 18^F-DOPA images were acquired at 6 different PET centers around the world and then analyzed at a single site. To our knowledge, this is the first time such a centralized approach has been employed with ^sup 18^F-DOPA PET and this descriptive basic science article ...

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