Norepinephrine Is a More Potent Inhibitor of Tumor Necrosis Factor Over a Range of Doses Than Dopamine

From: The American Surgeon | Date: June 1, 2004| Author: | Copyright information

In the current study, we test the hypothesis that norepinephrine has greater anti-inflammatory effects versus dopamine over a range of doses in a model of lipopolysaccharide (LPS)-stimulated cytokine release in human saphenous vein. Segments of saphenous vein were cut and separated into 1 mm × 1 mm squares and placed into two 24-well plates. These small segments of vessels were incubated in the presence of 20 µg/mL bacterial LPS, alone as a control or with 10×-6, 10×-5, 10×-4, 10×-3 concentration of dopamine or norepinephrine and LPS. The general linear models (GLM) statistical analysis ...

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