Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide1-4 From: The Journal of Nutrition | Date: June 1, 2004| Author: Johnson, W Thomas; DeMars, Lana C S | Copyright American Institute of Nutrition Jun 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT

The activity of hepatic heme oxygenase (HO) in rats is elevated in response to copper deficiency. However, the mechanism responsible for the increase in HO activity is poorly understood. Oxidative stress is a common denominator for many of the signals that induce HO-1, the inducible isoform of HO. The present study evaluated the role of H^sub 2^O^sub 2^ and the mitochondrial electron transport chain as a potential mechanism for the induction of HO-1 during copper deficiency. M...

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