A NOVEL CELL-BASED SYSTEM FOR EVALUATING SKELETAL MUSCLE CELL HYPERTROPHY-INDUCING AGENTS

In Vitro Cellular & Developmental Biology | November 1, 2003| | Copyright

SUMMARY

Skeletal muscle is a tissue that adapts to increased use by increasing contractile protein gene expression and ultimately skeletal muscle mass (hypertrophy). To identify hypertrophy-inducing agents that may be potentially useful in the treatment of age-related muscle loss (sarcopenia) and to better understand hypertrophy signal transduction pathways, we have created a skeletal muscle cell-based hypertrophy-responsive system. This system was created by permanently modifying the relatively undifferentiated C2C12 cell line so that it contains the [beta]-myosin heavy chain ([beta]-MHC) ...

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