Pancytopenia after removal of copper from total parenteral nutrition

From: JPEN, Journal of Parenteral and Enteral Nutrition | Date: November 1, 2000| Author: Fuhrman, M Patricia; Herrmann, Virginia; Masidonski, Patricia; Eby, Charles | Copyright information

ABSTRACT. Patients who develop cholestatic jaundice during chronic total parenteral nutrition (TPN) can develop significant hematologic complications due to hypocupremia if copper supplementation is withheld. A 36-year-old female with short bowel syndrome developed progressive liver dysfunction 6 months after initiation of TPN. Trace elements were omitted from her TPN because of cholestasis and persistent hyperbilirubinemia. Despite chronic diarrhea, absorption of some dietary copper was anti...

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