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Evaluation of toxicity and efficacy of (186)Re-hydroxyethylidene diphosphonate in patients with painful bone metastases of prostate or breast cancer
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Twenty-eight patients (12 men with prostate cancer, 16 women with breast cancer) were included in a phase II trial to evaluate the efficacy of 'ssRe-hydroxyethylidene diphosphonate (HEDP) on pain from bone metastasis and the toxicity of this agent.
Methods: After intravenous administration of 1295 MBq '86ReHEDP, the efficacy was evaluated by means of a daily log.
Results: We observed an objective response in 67% of prostate cancer patients and in 36% of breast cancer patients. The mean duration of response was 45 d for prostate cancer patients and 24 d for breast cancer patients. No major ...
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