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Dosimetry of Radioiodine Therapy in Patients with Nodular Goiter After Pretreatment with a Single, Low Dose of Recombinant Human Thyroid- Stimulating Hormone
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A single, low dose of recombinant human thyroid-stimulating hormone (rhTSH) doubles 24-h RAIU and causes a more homogeneous distribution of radioiodine on thyroid scintigrams of patients with nodular goiter. Pretreatment with rhTSH allows the therapeutic dose of ^sup 131^I to be reduced by 50%-60% without compromising the result of thyroid volume reduction. The present study focused on the dosimetric aspects of therapy with a reduced dose of ^sup 131^I after pretreatment with rhTSH in patients with nodular goiter. Methods: Thirty-six patients were treated with ^sup 131^I to reduce thyroid ...
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Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
; ^sup 111^In-Labeled antibodies and peptides have...used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent...significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium...
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Propylthiouracil Before ^sup 131^I Therapy
; ...propylthiouracil (PTU) before ^sup 131^I therapy affects...patients with toxic nodular goiter. Patients were randomized...pretreatment (n = 41) before ^sup 131^I therapy. The median...the group with toxic nodular goiter who had received pretreatment showed an ^sup 131^I ...
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Effects of Intracellular and Extracellular Concentrations of Ca^sup 2+^, K+, and Cl- on the Na+-Dependent Mg^sup 2+^ Efflux in Rat Ventricular Myocytes
; ABSTRACT Intracellular Mg^sup 2+^ concentration ([Mg^sup 2+^]^sub i^) was measured in rat ventricular myocytes with...indicator furaptra (25C). After the myocytes were loaded with Mg^sup 2+^, the initial rate of decrease in [Mg^sup 2+^]^sub i^ (initial...
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Processing of Generator-Produced ^sup 68^Ga for Medical Application
; The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled...
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Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]
; Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe...its leaves. Here we report that cAMP and Ca^sup 2+^ (blockers of nonselective cation channels...
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Thyrotropin Pretreatment in ^sup 131^I Therapy for Nodular Goiter
; ...undergoing therapy for nodular goiter, researchers from...reduced doses of ^sup 131^I. The article...22 patients with nodular goiter who received ^sup 131^I therapy 24...in patients with nodular goiter. Journal of Clinical...
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^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats
; ^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5...myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five...
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Recombinant Human Thyrotropin in ^sup 131^I Therapy
; ...human thyrotropin (rhTSH) on ^sup 131^I therapy in patients with nodular goiter were reported on October 19...were scheduled to undergo ^sup 131^I therapy for nodular cancer...remaining patients. Expected ^sup 131^I activity was calculated...of a tracer dose of 0.5 MBq ^sup 131^I. ...
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Comparison of ^sup 123^I and ^sup 131^I for Whole-Body Imaging in Thyroid Cancer
; We compared the diagnostic sensitivities of ^sup 123^I and ^sup 131^I whole-body imaging in differentiated thyroid cancer...thyroidectomized patients (3 previously treated with ^sup 131^I) were studied. After a period of thyroid hormone...
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Arabidopsis HMA2, a Divalent Heavy Metal-Transporting P^sub IB^-Type ATPase, Is Involved in Cytoplasmic Zn^sup 2+^ Homeostasis1
; P^sup IB^-type ATPases transport heavy metal ions (Cu^sup +^, Cu^sup 2+^, Zn^sup 2+^, Cd^sup 2+^, Co^sup 2+^, etc.) across biological membranes. Several members of this subfamily are present in plants. Higher plants are the only eukaryotes where putative...
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