HLA polymorphism and evaluation of European, African, and Amerindian contribution to the white and mulatto populations from Parana, Brazil

Human Biology | August 1, 2000| | Copyright

Abstract Polymorphism of classical HLA-A, HLA-B, HLA-C, HLA-- DR, and HLA-DQ genes differs greatly among populations, both in frequencies and in the presence of alleles and haplotypes particular to population groups, making these genes powerful tools for the study of origins of populations and their degree of admixture. Antigen, allele, and haplotype frequencies, together with linkage disequilibrium patterns, are reported for 2 populations in the southern Brazilian state of Parana, one of predominantly European ancestry (white), the other of predominantly African and European ancestry ...

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