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Physicochemical and Biological Data for the Development of Predictive Organophosphorus Pesticide QSARs and PBPK/PD Models for Human Risk Assessment
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ABSTRACT: A search of the scientific literature was carried out for physiochemical and biological data [i.e., IC^sub 50^, LD^sub 50^, K^sub p^ (cm/h) for percutaneous absorption, skin/water and tissue/blood partition coefficients, inhibition k^sub i^ values, and metabolic parameters such as V^sub max^ and K^sub m^] on 31 organophosphorus pesticides (OPs) to support the development of predictive quantitative structure-activity relationship (QSAR) and physiologically based pharmacokinetic and p...
Related newspaper, magazine, and journal articles from HighBeam Research
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Selected Traditional Structural Descriptors and R^sub M^ Values for Estimation and Prediction of Lipophilicity of Homologous Series of Saturated Fatty Acids
JAOCS, Journal of the American Oil Chemists' Society
; ABSTRACT: An homologous series of carboxylic FA, from methanoic to triacontanoic, were characterized by selected structural descriptors based on distance matrix (W, A, ^sup 0^B, ^sup 1^B), adjacency matrix (M, M^sup ν^, ^sup 0967;, ^sup 1967;, ^sup 2967;, ^sup 0967;^sup ν^, ^sup 1967;^sup
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PHYSIOLOGICALLY-BASED TOXICOKINETIC MODELING OF DURENE (1,2,3,5-TETRAMETHYLBENZENE) AND ISODURENE (1,2,4,5-TETRAMETHYLBENZENE) IN HUMANS
International Journal of Occupational Medicine and Environmental Health
; Abstract Objectives: Physiologically-based toxicokinetic (PB-TK) models are developed to simulate absorption, distribution and excretion of xenobiotics. PB-TK models consist of several groups of compartments, where tissues are grouped together according to physiological parameters (tissue blood
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Mobility and Persistence of Petroleum Hydrocarbons in Peat Soils of Southeastern Mexico
Soil & Sediment Contamination
; Spilled crude petroleum from oil wells contains numerous hydrocarbons, some of which are toxic and threaten life. We have studied the mobility and persistence of hydrocarbons in waterlogged soils that contain large proportions of fermented organic matter (Histosols) and large concentrations of
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Diffusion of macromolecules in membranes of hyalyronic acid ester
Biomedical Materials
; Biocompatible and biodegradable hyaluronate esters may be useful in peptide controlled release. Permeability and partition coefficients were measured for a series of solutes in membranes formed from ethyl or benzyl esters of the polysaccharide hyaluronic acid. The solutes were primarily peptides
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TEAM TO CREATE COMPUTER SYSTEM FOR BIOLOGICAL DATA
The Boston Globe
; The US Department of Energy, Celera Genomics Group, and Compaq Computer Corp. said they will team up to create a computer system capable of analyzing the ever-increasing volume of biological data. In four years, the group hopes to create a computing system that can process 100 trillion operations
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Laboratory studies of aqueous partitioning tracer tests for measuring nonaqueous phase liquid volumes
Water Environment Research
; ABSTRACT: The partitioning tracer test (PT) is an innovative method for measuring nonaqueous phase liquid (NAPL) volume distributions in contaminated aquifers. During a PTT, a tracer pulse containing nonpartitioning and partitioning tracers is injected to an aquifer and extracted from downgradient
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Absorption and drug development: solubility, permeability and charge state.(Book Review)
Chemistry and Industry
; Absorption and drug development: solubility, permeability and charge state A Avdeef Chichester: John Wiley & Sons, 2003 Drug development is one of the more glamourous areas of chemistry. Whether the image is of scientists in white coats synthesising innovative drugs in clean and well-equipped
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Solvent extraction principles and practice (2nd ed).
Chemistry and Industry
; Solvent extraction principles and practice (2nd ed) J Rydberg, M Cox, C Musikas and G Choppin (eds) New York: Marcel Dekker, 2004 Pages 750 195 [pounds sterling] ISBN 0 8247 5063 2 The prototypical separation process is distillation. That was what those hairy old alchemists did with their alembics
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ChemBio AE.(Chemistry)
Scientific Computing & Instrumentation
; ChemBio AE is a storage system for chemical data and a retrieval and viewing solution for chemical and biological data. Scientists can register single compounds or entire libraries, while the system automatically checks for duplicates, strips salts and solvents, assigns ID numbers, and calculates
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Electron Spin Resonance Investigation of Small Spin Probes in Aqueous and Vesicle Phases of Mixed Membranes Made from Poly(oxyethylene) Hydrogenated Castor Oil and Hexadecane
Lipids
; ABSTRACT: Small spin probes in the vesicle and aqueous phases of mixed membranes made from poly(oxyethylene) hydrogenated castor oil (HCO) and hexadecane were investigated by ESR (electron spin resonance) spectroscopy. Partitioning (partition coefficients), rotational correlation times, and
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