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Fetal Lungs of Tenascin-C-Deficient Mice Grow Well, but Branch Poorly in Organ Culture
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Tenascin-C (TNC) is a multidomain extracellular matrix protein that contributes to organogenesis and tumorgenesis. To elucidate its developmental function in the context of TNC deficiency, lung lobes of TNC null mice were obtained at Embryonic Days E11.5 and E12.5 and cultured for 3 d. In lung explants of homozygote TNC-deficient embryos (E12.5) the number of future airway branches was reduced by 36% as compared with wild-type. In heterozygote explants only half of the reduction (18%) was obs...
Related newspaper, magazine, and journal articles from HighBeam Research
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Regulation of Alveogenesis by Reciprocal Proximodistal Fibroblast Growth Factor and Retinoic Acid Signaling
American Journal of Respiratory Cell and Molecular Biology
; ... emerging technology that allows the generation of a highly detailed map of the gene expression from a given cell or tissue. These maps can be used to discriminate normal from abnormal conditions, as well as generate putative functional relationships between genes ...
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Keratinocyte Growth Factor Improves Repair in the Injured Tracheal Epithelium
American Journal of Respiratory Cell and Molecular Biology
; Keratinocyte growth factor (KGF) is a critical growth factor in lung development and is a protective agent after lung injury, although the exact mechanisms of this protective effect have not yet been elucidated. Our laboratory has shown that circulating epithelial progenitor cells can traffic to
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Defective pulmonary development in the absence of heparin-binding vascular endothelial growth factor isoforms
American Journal of Respiratory Cell and Molecular Biology
; Development of the airways, alveoli, and the pulmonary vasculature in the fetus is a process that is precisely controlled. One of the growth factors involved, vascular endothelial growth factor (VEGF), is so critical for embryonic development that in the mouse, elimination of just a single allele
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Mechanical Stretch Induces Fetal Type II Cell Differentiation Via an Epidermal Growth Factor Receptor-Extracellular-Regulated Protein Kinase Signaling Pathway
American Journal of Respiratory Cell and Molecular Biology
; Mechanical forces are important for fetal alveolar epithelial cell differentiation. However, the signal transduction pathways regulating this process remain largely unknown. Based on the importance of the extracellular-regulated protein kinase (ERK) pathway in cell differentiation, we hypothesized
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Vascular Endothelial Growth Factor Receptor 2 Blockade Disrupts Postnatal Lung Development
American Journal of Respiratory Cell and Molecular Biology
; Vascular endothelial growth factor (VEGF) is necessary for normal postnatal lung development and may underlie the structural lung damage that follows hyperoxic exposure. To determine the individual roles of VEGF receptors (VEGFR) 2 and 1 on postnatal lung growth, neonatal mice were treated with
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Bombesin-like peptides and airway repair: A recapitulation of lung development?
American Journal of Respiratory Cell and Molecular Biology
; Bombesin-like peptides (BLPs) are mammalian analogues of a peptide first isolated from frog skin (1). Recent studies (2-4) including those of Wang and associates in the American Journal of Respiratory Cell and Molecular Biology (5) have emphasized the role of one BLP, gastrin-releasing peptide
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Growth factor predicts cancer's spread.
Science News
; ... demonstration that a wide variety of tumors produced abnormally high levels of basic fibroblast growth factor, Folkman told SCIENCE NEWS. The researchers describe their work in the March 2 JOURNAL OF THE NATIONAL CANCER INSTITUTE. Compared to controls or cancer ...
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Conditional Overexpression of Bioactive Transforming Growth Factor-[beta]1 in Neonatal Mouse Lung: A New Model for Bronchopulmonary Dysplasia?
American Journal of Respiratory Cell and Molecular Biology
; Research interest in bronchopulmonary dysplasia (BPD) has steadily increased, and numerous potential mediators have been implicated in the development of the disease. Among such mediators is transforming growth factor (TGF946;. Unfortunately, commonly utilized murine transgenic models are not
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Factors Affecting Growth Factor Activity in Goat Milk
Journal of Dairy Science
; ABSTRACT Growth factors that are present in goat milk may be responsible for its beneficial effects on the digestive system as described in ancient Chinese medical texts. To develop a nutraceutical product rich in growth factors for promoting gastrointestinal health, it is essential to collect milk
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Man's heart given chance to grow its own bypass St. Francis Hospital tests procedure using genetically engineered growth factor
The Milwaukee Journal Sentinel
; A Milwaukee heart surgeon has injected a genetically engineered growth factor into a 72-year-old man's heart to help the heart develop brand-new blood vessels in effect growing a coronary artery bypass. Surgeon Dudley Johnson used an abandoned surgical procedure and a biological glue to enhance the
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