|
^sup 68^Ga-Labeled Oligonucleotides for In Vivo Imaging with PET
|
The biologic evaluation in living rats of ^sup 68^Ga-labeled oligonucleotides as imaging agents for PET is reported. Methods: ^sup 68^Ga, a positron-emitting radionuclide (half-life, 68 min), along with a macrocyclic chelating agent, 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA), was used for labeling of antisense oligonucleotides targeting activated human K-ras oncogene. The biologic properties of 3 different forms of the oligonucleotides-that is, 2'-deoxyphosphodieste...
Related newspaper, magazine, and journal articles from HighBeam Research
|
|
^sup 68^Ga-Labeled Oligonucleotides for In Vivo Imaging with PET
The Journal of Nuclear Medicine
; The biologic evaluation in living rats of ^sup 68^Ga-labeled oligonucleotides as imaging agents for PET is reported. Methods: ^sup 68^Ga, a positron-emitting radionuclide (half-life, 68 min), along with a macrocyclic chelating agent, 1,4,7,10-tetraazacyclododecane-N,N',NNtetraacetic acid (DOTA),
|
|
|
Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
The Journal of Nuclear Medicine
; ^sup 111^In-Labeled antibodies and peptides have been routinely used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent studies have shown that there are significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium
|
|
|
Synthesis and Biologic Evaluation of ^sup 64^Cu-Labeled Rhenium-Cyclized [alpha]-MSH Peptide Analog Using a Cross-Bridged Cyclam Chelator
The Journal of Nuclear Medicine
; Early detection of cutaneous melanoma is essential, as prognosis with metastatic melanoma is poor. Previous studies showed that ^sup 64^Cu-DOTA-ReCCMSH(Arg^sup 11^) (DOTA is 1,4,7,10-tetraazacyclododecane-N,N',NNtetraacetic acid), a cyclic analog of α-melanocyte-stimulating hormone 945;-MSH),
|
|
|
Optimization of Radioimmunotherapy of Renal Cell Carcinoma: Labeling of Monoclonal Antibody cG250 with ^sup 131^I, ^sup 90^Y, ^sup 177^Lu, or ^sup 186^Re
The Journal of Nuclear Medicine
; ... subcutaneous SK-RC-52 tumors. Mice received cG250 labeled with ^sup 131^I, ^sup 90^Y-SCN-BzDTPA, ^sup 177^Lu-SCN-Bz-DTPA, or ^sup 186^Re-MAGS intravenously at MTD (protein doses of 30, 30, 60, and 35 g per mouse, respectively). Mice in control groups received unlabeled ...
|
|
|
Development of a Novel ^sup 99m^Tc-Chelate-Conjugated Bisphosphonate with High Affinity for Bone as a Bone Scintigraphic Agent
The Journal of Nuclear Medicine
; In bone scintigraphy using ^sup 99m^Tc with methylenediphosphonate (^sup 99m^Tc-MDP) and hydroxymethylenediphosphonate (^sup 99m^Tc-HMDP), it takes 2-6 h after an injection before imaging can start. This interval could be shortened with a new radiopharmaceutical with higher affinity for bone. Here,
|
|
CD4^sup +^CD25^sup +^ Regulatory T Lymphocytes in Malignant Pleural Effusion
American Journal of Respiratory and Critical Care Medicine
; Background: Active suppression by CD4^sup +^CD25^sup +^ regulatory T lymphocytes plays an important role in the downregulation of T-cell responses to foreign and self-antigens. Objective: To analyze whether the CD4^sup +^CD25^sup +^ regulatory T lymphocytes exist and function normally in malignant
|
|
Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]
Plant Physiology
; Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe halophyte Suaeda maritima accumulates, without injury, concentrations of the order of 400 mM NaCl in its leaves. Here we report that cAMP and Ca^sup
|
|
|
^sup 203^Pb-Labeled [alpha]-Melanocyte-Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection
The Journal of Nuclear Medicine
; Peptide-targeted α-therapy with 7.4 MBq of ^sup 212^Pb-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-ReO-[Cys^sup 3,4,10^, D-Phe^sup 7^,Arg^sup 11945;-MSH^sub 3-13^ (^sup 212^Pb-DOTA-Re(Arg^sup 11^)CCMSH) cured 45% of B16/F1 murine melanoma-bearing C57 mice in a 120-d study,
|
|
|
Kinetic Analysis of ^sub 18^F-Fluorodihydrorotenone as a Deposited Myocardial Flow Tracer: Comparison to ^sup 201^Tl
The Journal of Nuclear Medicine
; The goals of this investigation were to assess the accuracy of ^sup 18^F-fluorodihydrorotenone (^sup 18^F-FDHR) as a new deposited myocardial flow tracer and to compare the results to those for ^sup 201^Tl. Methods: The kinetics of these flow tracers in 22 isolated, erythrocyte- and
|
|
|
^sup 99m^Tc-MAEC Complexes: New Renal Radiopharmaceuticals Combining Characteristics of ^sup 99m^Tc-MAG3 and ^sup 99m^Tc-EC
The Journal of Nuclear Medicine
; ^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3) and ^sup 99m^Tc-L,L-ethylenedicysteine (^sup 99m^Tc-LL-EC) are useful renal radiopharmaceuticals; however, both agents have renal clearances less than that of ^sup 131^I-orthoiodohippurate (^sup 131^I-OIH), and ^sup 99m^Tc-LL-EC exists in
|