Point Mutations Alter the Cellular Distribution of the Human Folate Receptor in Cultured Chinese Hamster Ovary Cells1,2

From: The Journal of Nutrition | Date: February 1, 2004| Author: | Copyright information

ABSTRACT Diminished cellular need for folate results in decreased function of the human folate receptor (FR) but increased expression of this protein in cells grown at different rates. Much of this FR is intracellular and not available for vitamin transport, raising the following question: what is the function of this excess receptor? In this study, we characterized the effects of three point mutations on FR regulation in Chinese hamster ovary cells stably transfected to express either wild-type receptor or FR containing mutations at positions 67^sub S[arrow right]P^,144^sub E[arrow right]D^, ...

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