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Reagents and Methods for PET Using Bispecific Antibody Pretargeting and ^sup 68^Ga-Radiolabeled Bivalent Hapten-Peptide-Chelate Conjugates
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The aim of this work was to develop reagents and methods potentially useful in PET, using ^sup 68^Ga in a 2-step pretargeting protocol. Methods: We prepared bispecific antibodies (bsAbs) for disease-specific targeting of carcinoembryonic antigen-positive cells and recognition of later-administered bivalent haptenpeptide conjugates. The secondary antibody arm (antibody 679) recognizes a histaminyl-succinyl-glycine (HSG) structural subunit. The bsAbs were prepared as Fab' Ã Fab' conjugates usi...
Related newspaper, magazine, and journal articles from HighBeam Research
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^sup 68^Ga-Labeled Peptides in Tumor Imaging
The Journal of Nuclear Medicine
; Radiolabeled peptides are of increasing interest in nuclear oncology. Special emphasis has been given to the development of peptides labeled with positron emitters. Among these, ^sup 68^Ga deserves special attention, because it is available from an in-house generator rendering ^sup 68^Ga
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Reagents and Methods for PET Using Bispecific Antibody Pretargeting and ^sup 68^Ga-Radiolabeled Bivalent Hapten-Peptide-Chelate Conjugates
The Journal of Nuclear Medicine
; The aim of this work was to develop reagents and methods potentially useful in PET, using ^sup 68^Ga in a 2-step pretargeting protocol. Methods: We prepared bispecific antibodies (bsAbs) for disease-specific targeting of carcinoembryonic antigen-positive cells and recognition of later-administered
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GRP Receptor-Targeted PET of a Rat Pancreas Carcinoma Xenograft in Nude Mice with a ^sup 68^Ga-Labeled Bombesin(6-14) Analog
The Journal of Nuclear Medicine
; Bombesin (BN), a 14-amino-acid peptide, shows high affinity for the human gastrin-releasing peptide receptor (GRP-r), which is overexpressed on several types of cancer, including prostate, breast, gastrointestinal, and small cell lung cancer. Thus, radio-labeled BN or BN analogs may prove to be
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Processing of Generator-Produced ^sup 68^Ga for Medical Application
The Journal of Nuclear Medicine
; The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled radiopharmaceuticals. The eluates have rather large
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Preparation, Biodistribution, and Small Animal PET of ^sup 45^Ti-Transferrin
The Journal of Nuclear Medicine
; Investigation of ^sup 45^Ti-transferrin was pursued to provide insight into the mechanism of action of titanocene dichloride, a chemotherapeutic agent currently in clinical trials. Methods: Plasma protein-binding studies of processed ^sup 45^Ti were performed by solubilizing the ^sup 45^Ti residue
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Molecular Characterization and Phylogeny of U2AF^sup 35^ Homologs in Plants1[W][OA]
Plant Physiology
; ... homologs (Atlg27650 and At5g42820; Wang and Brendel, 2004). Atlg27650 maps to the short arm of chromosome 1 and encodes a predicted polypeptide of 296 amino acids. At5g42820 maps to the long arm of chromosome 5 and encodes a predicted polypeptide of ...
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Preparation of a Promising Angiogenesis PET Imaging Agent: ^sup 68^Ga-Labeled c(RGDyK)-Isothiocyanatobenzyl-1,4,7-Triazacyclononane-1,4,7-Triacetic Acid and Feasibility Studies in Mice
The Journal of Nuclear Medicine
; Arg-Gly-Asp (RGD) derivatives have been labeled with various radioisotopes for the imaging of angiogenesis in ischemic tissue, in which α^sub v946;^sub 3^ integrin plays an important role. In this study, cyclic Arg-Gly-Asp-D-Tyr-Lys [c(RGDyK)] was conjugated with
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Synthesis and Biologic Evaluation of ^sup 64^Cu-Labeled Rhenium-Cyclized [alpha]-MSH Peptide Analog Using a Cross-Bridged Cyclam Chelator
The Journal of Nuclear Medicine
; Early detection of cutaneous melanoma is essential, as prognosis with metastatic melanoma is poor. Previous studies showed that ^sup 64^Cu-DOTA-ReCCMSH(Arg^sup 11^) (DOTA is 1,4,7,10-tetraazacyclododecane-N,N',NNtetraacetic acid), a cyclic analog of α-melanocyte-stimulating hormone 945;-MSH),
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Evaluation of [^sup 99m^Tc/EDDA/HYNIC^sup 0^]Octreotide Derivatives Compared with [^sup 111^In-DOTA^sup 0^,Tyr^sup 3^,Thr^sup 8^]Octreotide and [^sup 111^In-DTPA^sup 0^]Octreotide: Does Tumor or Pancreas Uptake Correlate with the Rate of Internalization?
The Journal of Nuclear Medicine
; Radiolabeled somatostatin analogs are important tools for the in vivo localization and targeted radionuclide therapy of somatostatin receptor-positive tumors. The aim of this study was to compare 3 somatostatin analogs designed for the labeling with ^sup 99m^Tc (where HYNIC is
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Preparation and Evaluation of ^sup 68^Ga-DOTA-hEGF for Visualization of EGFR Expression in Malignant Tumors
The Journal of Nuclear Medicine
; Detection of epidermal growth factor receptor (EGFR) overexpression in many carcinomas provides important diagnostic information, which can influence patient management. The use of PET may enable such detection in vivo by a noninvasive procedure with high sensitivity. The aim of this study was to
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