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Oxidative Stress and Apoptosis Interact and Cause Emphysema Due to Vascular Endothelial Growth Factor Receptor Blockade
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We have previously demonstrated that a failure of pulmonary endothelial cell survival induced by vascular endothelial growth factor (VEGF) receptor blockade results in lung alveolar septal cell apoptosis and emphysema. Because apoptosis and oxidative stress may be pathobiologically linked, we hypothesized that oxidative stress has a central role in alveolar septal cell apoptosis and emphysema induced by VEGF receptor blockade. When compared with control animals, rats treated with the VEGF rec...
Related newspaper, magazine, and journal articles from HighBeam Research
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Use of Biomarkers of Oxidative Stress in Research Studies1,2
The Journal of Nutrition
; EXPANDED ABSTRACT KEY WORDS: * biomarkers * oxidative stress * antioxidants In research studies, biomarkers can be employed to reflect environmental prooxidant exposures and dietary antioxidant intake or to serve as a surrogate measure of a disease process (1,2). To be truly useful, the biomarker
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Oxidative stress in humans during work at moderate altitude
The Journal of Nutrition
; Oxidative Stress in Humans during Work at Moderate Altitude1,2 ABSTRACT Increased oxidative stress has been associated with work at high altitude; however, it is not known whether oxidative stress is a significant problem at moderate altitudes. The oxidative stress indicators, breath pentane
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Oxidative stress in chronic kidney disease.(Issues in Renal Nutrition: Focus on Nutritional Care for Nephrology Patients)
Nephrology Nursing Journal
; Oxidative stress is defined as physiological stress on the body that is caused by the cumulative damage done by free radicals inadequately neutralized by antioxidants. It is imposed on cells as a result of an increase in the generation of oxidants, a failure to repair oxidative damage, or a
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Oxidative Stress Markers Are Associated with Persistent Atrial Fibrillation
Clinical Chemistry
; Background: Atrial fibrillation (AF) has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. We compared serum markers of oxidation and associated inflammation in individuals with or without AF. Methods: Serum markers of
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Dietary modification and moderate antioxidant supplementation differentially affect serum carotenoids, antioxidant levels and markers of oxidative stress in older humans1,2
The Journal of Nutrition
; Manuscript received 28 April 2003. Initial review completed 4 June 2003. Revision accepted 16 July 2003. ABSTRACT Oxidative stress is thought to be a factor in the progression of chronic diseases, and even the aging process itself. We examined the effect of two moderate vitamin, mineral and
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Increased Plasma Markers of Oxidative Stress Are Associated with Coronary Heart Disease in Males with Diabetes Mellitus and with 10-Year Risk in a Prospective Sample of Males
Clinical Chemistry
; Background: Increased oxidative stress is associated with coronary heart disease (CHD). We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a sample of men predominantly without diabetes.
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A Novel Antioxidant N-acetylcysteine amide Prevents HIV-1/gp120 and Tat-Induced Oxidative Stress in Brain Endothelial Cells
Clinical Chemistry
; D-129 T. Otamis Price1, F. Uras1, G. Goldstein2, W. A. Banks3, N. Ercal4. 1 Department of Biochemistry, Faculty of Pharmacy, University of Marmara, Istanbul, Turkey, 2 David Pharmaceticals, New York, NY, 3 Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of
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Oxidative stress response in Shigella & nonpathogenic gut bacteria
Indian Journal of Medical Research
; The effect of oxidative stress in the form of exogenous H202 on the survival of four species of Shigella and two nonpathogenic Gram negative gut bacteria and the role of catalase as an antioxidant enzyme, neutralizing the effect of H.02 were examined. A significant decrease in the number of colony
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Phytate-Rich Soy Protein Isolate May Protect against Oxidative Stress by Reducing Iron Stores in Postmenopausal Women
The Journal of Nutrition
; Oxidative stress is a major underlying cause of age-related diseases, including cardiovascular, cancer, and neurodegenerative conditions. Oxidative status typically decreases with age whereas body iron stores generally increase with age, especially after menopause. High iron stores may further
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Iron and oxidative stress in pregnancy1'2
The Journal of Nutrition
; ABSTRACT Pregnancy, mostly because of the mitochondria-rich placenta, is a condition that favors oxidative stress. Transitional metals, especially iron, which is particularly abundant in the placenta, are important in the production of free radicals. Protective mechanisms against free radical
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