RNA Polymerase II Association with the Phosphoenolpyruvate Carboxykinase (PEPCK) Promoter Is Reduced in Vitamin A-Deficient Mice1

From: The Journal of Nutrition | Date: December 1, 2003| Author: | Copyright information

ABSTRACT Phosphoenolpyruvate carboxykinase (PEPCK) gene expression is decreased in vitamin A-deficient (VAD) mice. However, the underlying molecular mechanism at the PEPCK promoter that contributes to this alteration in gene expression remains unexplained and thus serves as the basis for our investigation in this report. Using liver from vitamin A-sufficient (VAS) and VAD mice in the chromatin immunoprecipitation (ChIP) assay, we determined that histones H3 and H4 were in the acetylated or active state in VAS mice at each of the three retinoic acid response elements (RARE1, RARE2 and RARES) ...

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