Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women1,2 From: The Journal of Nutrition | Date: December 1, 2003| Author: Boelsma, Esther; van Vliet, Trinette; Verhoef, Petra; Olthof, Margreet R | Copyright American Institute of Nutrition Dec 2003. Provided by ProQuest LLC.Copyright information

ABSTRACT High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is ~0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma homocysteine concentrations in healthy adults. Four groups of 19 healthy subjects ingested three doses of betaine or placebo daily for 6 wk. A methionine loading test was performed during run in, on d 1 of ...

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