The Transcobalamin (TC) Codon 259 Genetic Polymorphism Influences Holo-TC Concentration in Cerebrospinal Fluid from Patients with Alzheimer Disease

From: Clinical Chemistry | Date: July 1, 2003| Author: Et al; Minthon, Lennart; Nexo, Ebba; Regland, Bjorn; Zetterberg, Henrik | Copyright information

Two proteins bind vitamin B^sub 12^ in plasma: haptocorrin (transcobalamin I) and transcobalamin (transcobalamin II; TC). The latter is the critical transporter that delivers vitamin B^sub 12^ to peripheral tissues. TC carries one-third of the circulating B^sub 12^ (holo-TC), but most TC is unsaturated (apo-TC) (1, 2). Polyacrylamide gel electrophoresis has revealed two common TC isotypes, M and X, and two rare variants, S and F (3, 4), that may influence the cellular availability of vitamin ...

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