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The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction
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The Role of Long-Chain Fatty Acyl-CoA Esters in beta-Cell Signal Transduction 1,2
ABSTRACT Glucose-induced insulin secretion is associated with inhibition of free fatty acid (FFA) oxidation, increased esterification and complex lipid formation by pancreatic beta-cells. Abundant evidence favors a role for cytosolic long-chain acyl-CoA (LC-CoA), including the rapid rise in malonyl CoA, the inhibitory effect of hydroxycitrate or acetyl CoA carboxylase knockout, both of which prevent malonyl CoA formation, and the stimulatory effect of exogenous FFA. On the other hand, some evidence opposes the ...
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A protein-restricted diet during pregnancy alters in vitro insulin secretion from islets of fetal winstar rats
; ...during Pregnancy Alters in Vitro Insulin Secretion from Islets of Fetal Wistar Rats1...ABSTRACT Previous studies indicate that insulin secretion from the fetuses of dams fed a low...study was to locate the defect in the insulin secretion pathway induced by a LP diet during...
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Low-Protein Diets Reduce PKA[alpha] Expression in Islets from Pregnant Rats1,2
; ...effect of protein restriction on insulin secretion and the expression of protein kinase...presence of 2.8 and 8.3 mmol glucose/L, insulin secretion by islets of CP rats was higher than...rats. Compared with the CN groups, insulin secretion by islets of LPN rats was lower with...
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Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion
; ABSTRACT Insulin secretion from pancreatic β-cells...profile it is necessary that the insulin secretion from individual β-cells...a model in which pulsatile insulin secretion is produced as a result of...
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Decreased Insulin Secretion in Islets from Rats Fed a Low Protein Diet Is Associated with a Reduced PKA[alpha] Expression1
; ...of several enzymes and to decrease insulin secretion by islets isolated from rats fed...stimulator of adenylyl cyclase, on insulin secretion by pancreatic islets from rats fed...forskolin/L. The forskolin-induced insulin secretion was higher in islets from NP rats...
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Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
; ...reported to be associated with impaired insulin secretion, insulin resistance and diminished...protein and mRNA levels, as well as insulin secretion and islet area, were measured after...normal protein diet after delivery. Insulin secretion by isolated islets in response to...
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Insulin resistance & secretion in subjects with normal fasting plasma glucose
; ...of FPG, insulin resistance (IR) and insulin secretion. We measured IR and insulin secretion in subjects with different levels...relationship between FPG and IR and insulin secretion, and to see whether lowering the cut-o...
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Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle
; ...CPT I; EC 2.3.1.21) to inhibition by malonyl CoA in rat heart and skeletal muscle. The...activity and sensitivity to inhibition by malonyl CoA can be shown to be regulated acutely...and a lower sensitivity of CPT I to malonyl CoA inhibition compared with rats fed a...
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Exenatide: A novel approach for treatment of type 2 diabetes.
; ...hormone that enhances glucose-induced insulin secretion after meals. In addition, GLP-1 stimulates...s) that enhanced glucose-induced insulin secretion from the pancreas. In 1969, Unger...carbohydrates, that stimulates pancreatic insulin secretion in the presence of glucose. ...
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Exenatide: An incretin-mimetic agent
; ...pathophysiological feature is either reduced insulin secretion or reduced insulin sensitivity resulting...degree of insulin resistance, impaired insulin secretion and increased glucose production...entry resulting in stimulation of insulin secretion (insulinotropism). Glucagon like...
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Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
; ...and Nutritional Recovery Modulate Insulin Secretion and the Early Steps of Insulin Action...leads to permanent alterations in insulin secretion and sensitivity of offspring. In...interactions better, we investigated the insulin secretion by isolated islets and the early...
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