Slower clearance of human SAA1.5 in mice: Implications for allele specific variation of SAA concentration in human From: Amyloid | Date: September 1, 2003| Author: Wada, Atsufumi; Yamada, Toshiyuki | Copyright CRC Press Sep 2003. Provided by ProQuest LLC.Copyright information

KEY WORDS: serum amyloid A, allele, isotype, amyloidosis, clearance

ABBREVIATIONS: SAA = serum amyloid A; HDL = high density lipoprotein; RA = rheumatoid arthritis; SDS-PAGE = sodium dodecyl sulfate-polyacrylamide gel electrophoresis

Abstract

Serum amyloid A (SAA), the serum precursor of the fibrillar component (AA proteins) in reactive amyloid deposits, is a multigene product. SAA1, the prominent acute phase isotype in serum and also the dominant fibril precursor, has se...

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