A tale of two transporters

From: The Scientist | Date: November 17, 2003| Author: | Copyright information

hot PAPERS

The first high-resolution structures both please and puzzle the ABC transporter field

The ATP binding cassette transporters epitomize nature's ability to re-use a successful protein motif. With diverse membrane-spanning regions, but highly conserved soluble ATP binding domains, the ABC transporters serve a wide variety of functions and are defunct in disorders such as Tangier disease and cystic fibrosis (see pg. 21). Small wonder then, that the first high-resolution structures of this largest family of transporters were greeted with great acclaim. But there was puzzlement as well; ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Simulation of the Coupling between Nucleotide Binding and Transmembrane Domains in the ATP Binding Cassette Transporter BtuCD
; ...structural rearrangements in ATP binding cassette (ABC) transporters, leading to substrate translocation...proteins containing the ATP binding cassette (ABC) motif (1...understand in detail how ABC transporters use ATP to facilitate transport...
How Does Protein Architecture Facilitate the Transduction of ATP Chemical-Bond Energy into Mechanical Work? The Cases of Nitrogenase and ATP Binding-Cassette Proteins
; ...adenosine triphosphate (ATP) binding and hydrolysis...nitrogenase and the ATP binding-cassette vitamin...complex triggered by ATP binding to the Fe protein...the edges of the ATP binding sites and the...al., 2000a) show ATP binding and ...
Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development
; ...analysis of the 29 ABC transporters present in the yeast...been adopted for the ABC transporters present in plants...followed by a cytoplasmic ATP binding domain, which is followed...domains and another ATP binding domain. Thus, MDR...new field of plant ABC ...
PGP4, an ATP Binding Cassette P-Glycoprotein, Catalyzes Auxin Transport in Arabidopsis thaliana Roots(W)
; Members of the ABC (for ATP binding cassette) super-family...MDR/PGP) subfamily of ABC transporters have been shown to...INTRODUCTION Members of the ATP binding cassette (ABC) transporter superfamily...al., 1997). Although ABC transporters are often ...
A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik
; ...the mitochondrial ABC transporter Staff...Arabidopsis half-ABC transporters. The severity of...function of Atml p-like ABC transporters. INTRODUCTION ABC transporters constitute one of...highly conserved ATP binding cassette, which...gradient. The typical ...
Scientists Establish Database of Cancer Drug Resistant Genes
; ...family of proteins called ABC transporters. The NCI scientists identified...expression of individual ABC transporters in cancer cells and resistance...specific drugs. Although ABC transporters are primarily associated...
Altered Profile of Secondary Metabolites in the Root Exudates of Arabidopsis ATP-Binding Cassette Transporter Mutants1[C][W][OA]
; ...suggesting a role for ATP-binding cassette (ABC) transporters in root exudation of phytochemicals...selected six full-length ABC transporters and a half-size transporter...partially controlled by ABC transporters. The primary functions...
Nucleotide-Dependent Conformational Changes in HisP: Molecular Dynamics Simulations of an ABC Transporter Nucleotide-Binding Domain
; ...and eukaryotes. In ABC transporters, solute translocation...INTRODUCTION Members of the ATP-binding cassette (ABC) transporter...mutations in mammalian ABC transporters lead to (or prevent...diabetes, and cancer. ABC transporters comprise two ...
An ATP-binding cassette transporter GhWBC1 from elongating cotton fibers1
; ...hirsutum) that encodes an ATP-binding cassette transporter of...development and elongation. The ATP-binding cassette (ABC) transporters, known for their function...Theodoulou, 2000). Functional ABC transporters typically consist of two...partners. In bacteria, many ...
Pathogen-responsive expression of a putative ATP-binding cassette transporter gene conferring resistance to the diterpenoid sclareol is regulated by multiple defense signaling pathways in Arabidopsis1
; The ATP-binding cassette (ABC) transporters are encoded by large...the molecular level. ATP-binding cassette (ABC)-type membrane proteins (ABC transporters) function as ATP-driven...Although approximately 131 ABC transporters have been ...