Histidine-imbalanced diets stimulate hepatic histidase gene expression in rats From: The Journal of Nutrition | Date: November 1, 1999| Author: | Copyright American Institute of Nutrition Nov 1999. Provided by ProQuest LLC.Copyright information

Histidine-Imbalanced Diets Stimulate Hepatic Histidase Gene Expression in Raft1

ABSTRACT A high protein concentration in the diet induces the gene expression of several amino acid degrading enzymes such as histidase (Hal) in rats. It is important to understand whether the amino acid pattern of the dietary protein affects the gene expression of these enzymes. The purpose of the present work was to study the effect of a histidine-imbalanced diet on the activity and mRNA concentration of rat hepatic histidase. Seven groups of six rats were fed one of the following diets: 1) 6% casein (basal), ...

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