Plasma total homocyst(e)ine may not be the most appropriate index for cardiovascular disease risk

The Journal of Nutrition | October 1, 1999| | Copyright

2 Abbreviations used: Hcy, homocyst(e)ine; Lp(a), lipoprotein (a); 5-MTHF, 5-methyltetrahydrofolate; MTHFR, 5,10-methylenetetrahydrofolate reductase; tHcy, total homocyst(e)ine.

OVERVIEW OF HOMOCYST(E)INE METABOLISM

Homocyst(e)ine (Hcy)2 is a naturally occurring, sulfurcontaining amino acid. It exists as either free homocysteine or protein-bound homocystine. Free homocysteine is comprised of three distinct fractions, i.e., reduced homocysteine, homocysteine-homocysteine disulfide (homocystine) and cysteinehomocysteine (Cys-Hcy) mixed disulfide. Homocystine and the Cys-Hcy mixed disulfide ...

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