Imaging central nicotinic acetylcholine receptors in baboons with [18F]fluoro-A-85380

From: The Journal of Nuclear Medicine | Date: August 1, 1999| Author: Valette, Heric; Bottlaender, Michel; Dolle, Frederic; Guenther, Ilonka; Et al | Copyright information

Central nicotinic acetylcholine receptors (nAChRs) have been implicated in learning-memory processes. Postmortem brain tissue of patients who suffered senile dementia or Parkinson's disease shows low density of nAChRs. In this study, we used PET to evaluate the distribution and kinetics of the fluoro derivative of the high-affinity and (alpha)4(beta)2-subtype-selective, nicotinic ligand 3-[2(S)-2-azetidinylmethoxy]pyridine (A-85380) in baboons. Methods: After intravenous injection of 37 MBq (...

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