Quantitative real-time PCR compared with pp65 antigen detection for cytomegalovirus (CMV) in 1122 blood specimens from 77 patients after allogeneic stem cell transplantation: Which test better predicts CMV disease development?

From: Clinical Chemistry | Date: October 1, 2003| Author: Et al; Oswald, Olivia; Schetelig, Johannes; Steuer, Nina; Nitsche, Andreas | Copyright information

Cytomegalovirus (CMV) can compromise the life of patients who are immunosuppressed after organ transplantation or who have acquired immunodeficiency syndrome. CMV infections or reactivations can be successfully treated, provided treatment is instituted early in the course of developing disease. Current assays to detect the CMV pp65 antigen in peripheral blood leukocytes or CMV DNA by qualitative PCR of leukocytes or plasma can be slow and tedious (1-3). Antigen detection is limited by the ava...

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