Myocardial glucose uptake measured with fluorodeoxyglucose: A proposed method to account for variable lumped constants

From: The Journal of Nuclear Medicine | Date: July 1, 1999| Author: | Copyright information

Quantitative assessment of myocardial glucose uptake by the glucose tracer analog 2-deoxy-2-[^sup 18^F]fluoro-D-glucose (FDG) depends on a correction factor (lumped constant [LC]), which may vary. We propose that this variability is caused by different affinities of FDG and glucose for membrane transport and phosphorylation and can be predicted from the time course of FDG retention. We therefore measured the LC under steadystate metabolic conditions and compared the results with values predicted from the tracer retention alone. Methods: We measured rates of myocardial glucose uptake by tracer ...

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