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Smoke and C5a induce airway epithelial intercellular adhesion molecule-1 and cell adhesion
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The human bronchial epithelial cell is one of the first cell types to be exposed to the irritants and toxins present in inhaled cigarette smoke. The ability of the bronchial epithelium to modulate inflammatory and immune events in response to cigarette smoke is important in the pathogenesis of smoke-induced airway injury. We have shown that cigarette smoke extract and the complement anaphylatoxin C5a both independently induce increased expression of intercellular adhesion molecule (ICAM)-1 on...
Related newspaper, magazine, and journal articles from HighBeam Research
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Cigarette smoke inhibits human bronchial epithelial cell repair processes
American Journal of Respiratory Cell and Molecular Biology
; By interfering with the ability of airway epithelial cells to support repair processes, cigarette smoke could contribute to alterations of airway structures and functions that characterize chronic obstructive pulmonary disease (COPD). The current study assessed the ability of cigarette smoke
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Cigarette Smoke Triggers Code Red: p21^sup CIP1/WAF1/SDI1^ Switches on Danger Responses in the Lung
American Journal of Respiratory Cell and Molecular Biology
; The article by Yao and coworkers in this issue (Am. J. Respir. Cell Mol. Biol. 2008;39:7-18) reveals that the cyclin-dependent kinase inhibitor p21CIP1/WAF1/SDI1 (designated hereafter as p21), which has been linked to cell cycle growth arrest due to stress or danger cell responses, may modulate
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Cigarette Smoke Synergistically Enhances Respiratory Mucin Induction by Proinflammatory Stimuli
American Journal of Respiratory Cell and Molecular Biology
; Pathogenic factors associated with chronic obstructive pulmonary disease (COPD), such as cigarette smoke, proinflammatory cytokines, and bacterial infections, can individually induce respiratory mucins in vitro and in vivo. Since co-presence of these factors is common in lungs of patients with
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Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats1,2
The Journal of Nutrition
; Manuscript received 14 March 2003. Initial review completed 8 April 2003. Revision accepted 15 May 2003. ABSTRACT We showed previously that vitamin A deficiency per se causes emphysema. Benzo(a)pyrene, a constituent in cigarette smoke, induces vitamin A depletion when administered to rats;
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Effects of Cigarette Smoke and Alcohol on Ciliated Tracheal Epithelium and Inflammatory Cell Recruitment
American Journal of Respiratory Cell and Molecular Biology
; Ciliated epithelium represents the first line of host defense against lung infection. Most alcoholics smoke and are at high risk for developing lung infections. We reported that cigarette smoke activates protein kinase C (PKC) and alcohol desensitizes ciliary beat frequency (CBF) to β-agonists
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Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness
American Journal of Respiratory and Critical Care Medicine
; Epidemiologie studies suggest that in utero exposure to tobacco smoke, primarily through maternal smoking, increases the risk for asthma in children; however, the mechanism of this phenomenon is not clear. Cyclic adenosine monophosphate relaxes airway smooth muscles in the lung and acts as an
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New study suggests cigarette smoke may play large role in miscarriages
The Boston Globe
; MONTREAL -- Cigarette smoke may cause a catastrophic disruption of the chromosomes in human eggs that can lead to miscarriage, researchers say. The researchers found nicotine and cadmium, another component of cigarette smoke, in the fluid that surrounds maturing eggs just before they are
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¿,ß-Unsaturated Aldehydes in Cigarette Smoke Release Inflammatory Mediators from Human Macrophages
American Journal of Respiratory Cell and Molecular Biology
; Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD is a condition associated with chronic pulmonary inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including
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Cigarette Smoke Decreases Pulmonary Dendritic Cells and Impacts Antiviral Immune Responsiveness
American Journal of Respiratory Cell and Molecular Biology
; We investigated the impact of cigarette smoke exposure on respiratory immune defense mechanisms. Mice were exposed to two cigarettes daily, 5 d/wk, for 2-4 mo. Tobacco smoke decreased the number of dendritic cells (DCs) in the lung tissue. Furthermore, smoke exposure dramatically reduced the
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Cigarette Smoke Alters Human Vitamin E Requirements1,2
The Journal of Nutrition
; ABSTRACT Vitamin E is a lipophilic chain-breaking antioxidant that prevents lipid peroxidation. Although cigarette smoke is a potent source of oxidative stress that depletes vitamin E in vitro, it is unclear whether it has a similar effect in vivo, particularly in humans. Therefore, this review
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