Chronic infusion of interleukin 1 induces hyperlactatemia and altered regulation of lactate metabolism in skeletal muscle

From: JPEN, Journal of Parenteral and Enteral Nutrition | Date: July 1, 1999| Author: | Copyright information

ABSTRACT. Background: Hyperlactatemia is observed commonly in patients with severe inflammation syndrome or sepsis. Elevated plasma lactate concentrations may be caused by cytokine-mediated alterations in specific organ systems responsible for lactate homeostasis. The role of interleukin 1 (IL-1) in inducing hyperlactatemia and derangements in skeletal muscle and hepatic lactate metabolism was investigated by examining the consequences of infusing IL-1 continuously into normal rats. Methods: Male Sprague-Dawley rats were anesthetized, and catheters were placed in the jugular vein. Rats were ...

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