The iso-competition point for counterion competition binding to DNA: Calculated multivalent versus monovalent cation binding equivalent

From: Biophysical Journal | Date: July 1, 1999| Author: | Copyright information

ABSTRACT In this paper we introduce an important parameter called the iso-competition point (ICP), to characterize the competition binding to DNA in a two-cation-species system. By imposing the condition of charge neutralization fraction equivalence theta^sub 1^ = Ztheta^sub z^ upon the two simultaneous equations in Manning's counterion condensation theory, the ICPs can be calculated. Each ICP, which refers to a particular multivalent concentration where the charge fraction on DNA neutralized from monovalent cations equals that from the multivalent cations, corresponds to a specific ionic ...

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