Molecular biology approaches help piece together puzzle of EHK

From: Dermatology Times | Date: June 1, 1999| Author: | Copyright information

New Orleans -- While many questions remain, implementation of molecular genetic approaches has led to an improved understanding of the etiology of epidermolytic hyperkeratosis (EHK), John J. DiGiovanna, M.D., said at the annual meeting of the American Academy of Dermatology.

To date, mutations in genes coding for keratin 1 and keratin 10 have been identified in patients with generalized EHK. However, mutations have not been found in about one-third of families tested. In addition, a new classification system for this disease has been developed based on clinical appearance, and some ...

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