Effects of recombinant human superoxide dismutase during reoxygenation with 21% or 100% oxygen after cerebral asphyxia in newborn piglets

From: Journal of Maternal - Fetal & Neonatal Medicine | Date: August 1, 2003| Author: | Copyright information

Objective: Superoxide radicals (O^sup -^^sub 2^) are generated during rcoxygenation following asphyxia, possibly more when higher concentrations of O2 are used during resuscitation. Superoxide dismutase (SOD) is an antioxidant enzyme, which scavenges O^sup -^^sub 2^. We tested the hypothesis that a single intravenous dose of recombinant human Cu,Zn SOD (rhSOD) could influence microcirculation and biochemical markers of asphyxia in piglets reoxygenated with 21% or 100% O2 after combined cerebral hypoxemia-ischemia-hypercapnia.

Methods: Anesthetized newborn piglets were randomized to asphyxia ...

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