Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens[para]

From: Photochemistry and Photobiology | Date: July 1, 2003| Author: | Copyright information

Received 7 January 2003; accepted 3 April 2003

ABSTRACT

Hypericin is the ingredient used to standardize the popular over-the-counter antidepressant medication St. John's Wort. Because hypericin readily produces singlet oxygen and other excited state intermediates, it is a very efficient phototoxic agent in the eye that can potentially induce the development of the cataract photooxidative mechanism. Hypericin absorbs in the UV and visible ranges, binds to the lens crystalline ([alpha], [beta] and [gamma]) and damages these proteins through a photooxidative mechanism. Effects were measured ...

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